BLife Therapeutics intends to launch clinical trials of AP-003 to test the efficacy of IFNa2b for treatment of COVID-19



Blife Therapeutics intends to launch clinical trials to test the efficacy of IFNa2b for treatment of Covid 19. AP-003 is being developed as a novel interferon alpha2b (IFNa2b) inhalation formulation.

IFNa2b has been used to treat COVID 19 in China.²

Subject to receiving marketing authorization, AP-003 could potentially be used to treat patients early after COVID 19 infection which may potentially prevent the progression to severe disease and need for hospitalization.³

If successful in clinical trials, AP-003 may potentially be positioned as an initial treatment for COVID 19 and similar viruses.

For more information please see the full investor presentation.


  1. Subject to successful outcome of clinical trials and obtaining market authorization
  2. Dong et al, 2020; Lu, 2020; Shen & Yang, 2020; Zhou et al, 2020
  3. Altum Clin Protocol ALT 003 COV 01 2020 04 30

Why AP-003


SARS CoV 2 coronavirus causes COVID 19. SARS CoV viruses block interferon production in infected cells, allowing the virus to continue replicating unabated ¹.

Treatment with interferon may overcome that block, potentially restoring cells normal anti viral activity.

Interferon alpha 2b (IFNa2b) is a potential treatment for COVID 19 ².

IFNa2b (inhaled) has been used in China on COVID 19 patients.

AP-003 may be given by inhalation at the first signs of COVID 19 with following projected outcomes according to Altum Clin Protocol ALT 003 COV 01 2020 05 04 rationale:


  • AP-003 inhalation applies INFa2b directly to the lungs which may enable infected cells to halt viral replication.
  • AP-003 inhalation may help to restore the initial immune response to COVID 19.
  • AP-003 inhalation 1st proposed target indication: people at higher risk to develop severe COVID 19 disease
  • Potential Result: Reduction of the overall hospitalization rate, long term tissue damage and death by reducing the severity of the disease
  • Potential prevention of long term damage to the lung, heart, kidney and the brain


Response to Viral Infection

Typical Response to Viral Infection

When a virus invades a cell, interferon is produced resulting in inhibition of viral replication. The Immune response proceeds to eradicate remaining virus in an orderly fashion, without damaging normal tissues.

When COVID-19 invades a cell, interferon production is thought to be blocked resulting in uncontrolled viral replication. By the time the immune system responds to the large viral load, there is already viral-related tissue damage. A massive outpouring of cytokines and antibodies believed to create a ‘cytokine storm’ causing extensive further tissue damage.

Administration of AP-003 may bypass interferon blockade in the cells and may restore IFN inhibition of viral replication so there is a normal immune response.

Investor Overview


BLife Therapeutics is a subsidiary of Better Life Pharmaceuticals Inc., a biopharmaceutical company engaged in the development and commercialization of therapeutic pharmaceuticals and nutraceuticals using innovative drug delivery platform technologies. Our shares are publicly-traded on the CNX under the ticker symbol “BETR” and on the OTCQB under the ticker symbol “PVOTF”

BLife Therapeutics Investor Presentation





Our Leadership Team


BetterLife has assembled a highly experienced management team that has clinical, commercial, product development and financial experience

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